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What instruments in biopharmaceutical processes require cooling water systems?

1.Bioreactor: During large-scale cell culture, fermentation, and other biochemical reactions, the internal temperature of the reactor needs to be precisely controlled, and the cooling water system can be used to carry away a large amount of heat generated by the reaction and maintain a constant reaction temperature.

2.Ultra low temperature refrigerators and cryostorage equipment: Used for storing biological samples and reagents, especially for long-term storage of biological products such as cell lines, DNA samples, protein solutions, etc. The cooling system ensures that the samples are in a suitable low-temperature environment.

3.Centrifuge: During high-speed centrifugal separation, a large amount of heat is generated, especially in large desktop or floor type centrifuges. The cooling water circulation system helps to quickly dissipate heat and protect sensitive samples from high temperatures.

4.Chromatographic system: including high-performance liquid chromatography (HPLC), ion chromatography (IC), gas chromatography (GC), etc. The pumps, detectors, and other components used in the analysis and purification process may generate a large amount of heat, requiring a cooling water system to cool down.

5.Freeze dryer: During the freeze-drying process, the cooling system is not only used for the early freezing step, but also for the later sublimation drying stage. The condenser part captures and condenses the sublimated water through the cooling water system.

6.Steam compression sterilizer: After sterilization, the cooling water system helps to quickly cool the load, reduce waiting time, and improve work efficiency.

7.Laboratory heating and cooling equipment: Instruments such as PCR machines, electrophoresis machines, enzyme-linked immunosorbent assay (ELISA) machines that may generate or require low temperature conditions during the experiment also require support from a cooling water system.

8.Drug crystallization equipment: Accurate temperature control is required during the drug crystallization process, and the cooling water system helps maintain a constant temperature in the crystallization bath.

Purified water system and injection water system: In order to maintain stable water quality, avoid bacterial growth, and timely discharge the heat generated by distillation, reverse osmosis and other processes during water purification, a cooling water system will also be equipped.